2022   03   en   p.39-47 Hüseyin Okan Durmuş1,2, Mirhasan Yu. Seyidov1,
Measurement of internal and surface temperatures and optical properties of Zerdine phantom under 635 nm low level laser irradiation


In this study, internal and surface temperatures of the Zerdine phantom used as reference material in the ultrasonic imaging processes and its optical properties such as absorbance, transmittance, reflectance, refractive index, and optical attenuation coefficient were investigated by using a low-level laser device which has a 635 nm wavelength. Internal temperatures and the said optical properties were measured successfully. However, due to the transparent color nature of the Zerdine phantom, significant temperature increases could not be detected at the surface of the phantom. Therefore, the phantom material was colored at different concentrations with a color tone close to human skin, and thus surface temperatures were measured in this way. However, it was determined that surface temperature values did not increase too much with increasing color concentration. Therefore, it has been concluded that the use of Zerdine phantom as an ideal background reference material in optical imaging studies makes it advantageous because of its transparent color nature and low optical absorbance value.

Keywords: Low-Level Laser, Zerdine Phantom, Internal and Surface Temperature Measurements, Optical Properties.

Received: 05.09.2022


1. Department of Physics, Gebze Technical University, 41400, Kocaeli, Turkey
2. Medical Metrology Laboratory, TUBITAK National Metrology Institute (TUBITAK UME), 41470, Kocaeli, Turkey
E-mail: hokandurmus@gtu.edu.tr, smirhasan@gtu.edu.tr

[1]   M.A. Ansari ve E. Mohajerani. «Mechanisms of Laser-Tissue Interaction: I. Optical Properties of Tissue», Journal of Lasers in Medical Sciences, cilt 2, № 3, pp. 119-125, Summer 2011.
[2]   Q. Peng, A. Juzeniene, J. Chen, L.O. Svaasand, T. Warloe, K.E. Giercksky, J. Moan. 2008. Lasers in medicine. Reports on Progress in Physics, 71(5), 056701.
[3]   L.O. Svaasand. «Laser-tissue interaction,» Proc. SPIE 1524, Bioptics: Optics in Biomedicine and Environmental Sciences, pp. 1-13, 1992.
[4]   B. Dinç ve M.E. Or. «Farklı Tipte Lazerlerin Veteriner Hekimlikte Kullanımı,» TÜBAV Bilim, cilt 7, № 3, pp. 1-10, 2014.
[5]   Z. Husain ve T.S. Alster. «The role of lasers and intense pulsed light technology in dermatology», Clinical, Cosmetic and Investigational Dermatology, № 9, pp. 29-40, 2016.
[6]   K.J. Ahn, B.J. Kim ve S.B. Cho. «Tissue-Mimicking Phantom Useful in Simulating Laser Light Tissue Interactions» Medical Lasers, cilt 4, № 2, pp. 86-88, 2015.
[7]   Y. Alipanah, M. Asnaashari ve F. Anbari. «The effect of low level laser (GaAlAs) therapy on the post-surgical healing of full thickness wounds in rabbits», Medical Laser Application, № 26, pp. 133-138, 2011.
[8]   H.B. Cotler, R.T. Chow, M.R. Hamblin, J. Carroll. 2015. The use of low level laser therapy (LLLT) for musculoskeletal pain. MOJ orthopedics & rheumatology, 2(5).
[9]   G.K. Reddy, L. Stehno-Bittel, C.S.Enwemeka. 1998. Laser photostimulation of collagen production in healing rabbit Achilles tendons. Lasers in Surgery and Medicine: The Official Journal of the American Society for Laser Medicine and Surgery, 22(5), 281-287.
[10]  A.L. McKenzie. «Physics of thermal processes in laser-tissue interaction», Phys. Med. Biol., cilt 35, № 9, pp. 1175-1209, 1990.
[11]  B. Karaböce. 2015, May. Focused ultrasound temperature effect in tissue-mimicking material and sheep liver. In 2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings (pp. 131-134). IEEE.
[12]  B. Karaböce, H.O. Durmuş. 2015. Visual investigation of heating effect in liver and lung induced by a HIFU transducer. Physics Procedia, 70, 1225-1228.
[13]  B. Karaböce, E. Çetin, H.O. Durmuş. 2016, May. Investigation of temperature rise in tissue—Mimicking material induced by a HIFU transducer. In 2016 IEEE International Symposium on Medical Measurements and Applications (MeMeA) (pp. 1-6). IEEE.
[14]  B. Karaböce, E.Çetin, H.O. Durmuş, M. Özdingiş, H. Öztürk, K. Mahmat, M. A. Güler. 2018, June. Investigation of Different TMMs in High Intensity Focused Ultrasound Applications. In 2018 IEEE International Symposium on Medical Measurements and Applications (MeMeA) (pp. 1-5). IEEE.
[15]  B.W. Pogue, M.S. Patterson. 2006. Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry. Journal of biomedical optics, 11(4), 041102.
[16]  İ. Akkaya, M. Engin, Y. Öztürk. Doku Fantom Üretimi ve Temel Optik Özelliklerinin Ölçümü/Fabrication of Tissue Phantom and Measurement of The Fundamental Optical Properties. Celal Bayar Üniversitesi Fen Bilimleri Dergisi, 13(1), 2017, 205-209.
[17]  J. ZHANG, L.I.U. Yuanjie, J.ROBIC, A. NKENGNE, Y.A.N. Hong, X. ZHANG, SOO, X.Y. 2019. Optical Phantom Development for Skin Measurement. In 19th International Congress of Metrology (CIM2019) (p. 19001). EDP Sciences.
[18]  R. Srinivasan, D. Kumar, M. Singh. 2002. Optical tissue-equivalent phantoms for medical imaging. Trends Biomater. Artif. Organs, 15(2), 42-47.
[19]  R.A. Jaime, , Basto, R.L., Lamien, B., Orlande, H.R., Eibner, S., & O. Fudym, (2013). Fabrication methods of phantoms simulating optical and thermal properties. Procedia Engineering, 59, 30-36.
[20]  A.I. Chen, M.L. Balter, M.I. Chen, D. Gross, S.K. Alam, T.J. Maguire, M.L. Yarmush. 2016. Multilayered tissue mimicking skin and vessel phantoms with tunable mechanical, optical, and acoustic properties. Medical Physics, 43 (6), 3117-3131.
[21]  P. Lai, X. Xu, L.V. Wang. 2014. Dependence of optical scattering from Intralipid in gelatin-gel based tissue-mimicking phantoms on mixing temperature and time. Journal of biomedical optics, 19(3), 035002.
[22]  E. Dong, Z. Zhao, M. Wang, Y. Xie, S. Li, P. Shao, R.X. Xu. 2015. Three-dimensional fuse deposition modeling of tissue-simulating phantom for biomedical optical imaging. Journal of biomedical optics, 20(12), 121311.
[23]  M.Y. Nadeem, W. Ahmed. 2000. Optical properties of ZnS thin films. Turkish Journal of Physics, 24(5), 651-659.
[24]  D.T. Harvey. 2003. Analytical Chemistry for Technicians, 3rd Edittion, page 193, (John Kenkel).
[25]  S. Chang, A.K. Bowden. 2019. Review of methods and applications of attenuation coefficient measurements with optical coherence tomography. Journal of biomedical optics, 24(9), 090901.
[26]  J. Fraser, R. Williams. 2009. Page 192, Handbook of Forensic Science.